2000 Edmonton Eskimos
Edmonton finished with a 10-8 record, second in the West Division. They would go on to lose in the West Semifinal to the B.C. Lions. This would mark the end of Don Matthews as head coach in Edmonton. The great Henry “Gizmo” Williams would call it a career following the season and would leave being the leading kick-returner of all-time.
In the regular season Nealon Greene threw for 3,059 yards and Terry Vaughn had 94 receptions for 1,216 yards and six touchdowns.
Danny Bass and Hugh Campbell (Builder) are inducted into the Canadian Football Hall of Fame.
| 2000 (52nd season) |
| Record: 10-8 (2nd West) |
| Home: 5-4 | Away: 5-4 |
| Playoffs: 0-1 | Lost Division Semifinal |
| Head coach: Don Matthews (2nd season) |
| CFL All-Stars: Bruce Beaton, Terry Ray |
| West All-Stars: Bruce Beaton, Leo Groenewegen, Terry Ray, Ralph Staten, Terry Vaughn |
| Hall of Fame: Danny Bass, Hugh Campbell (Builder) |
| Major award winners: |
| Wall of Honour: |
| Date | Opponent | Result (record) |
| July 5 | at Calgary Stampeders | L 44–22 (0-1) |
| July 14 | vs Hamilton Tiger-Cats | L 28–21 (0-2) |
| July 21 | vs Winnipeg Blue Bombers | W 51–49 (1-2) |
| July 27 | at British Columbia Lions | W 29–13 (2-2) |
| August 4 | at Hamilton Tiger-Cats | W 16–10 (3-2) |
| August 11 | vs Montreal Alouettes | W 29–7 (4-2) |
| August 18 | at Saskatchewan Roughriders | W 28–22 (5-2) |
| August 25 | vs Saskatchewan Roughriders | L 30–20 (5-3) |
| September 4 | at Calgary Stampeders | W 30–1 (6-3) |
| September 8 | vs Calgary Stampeders | W 31–10 (7-3) |
| September 16 | at British Columbia Lions | L 26–14 (7-4) |
| September 22 | vs Toronto Argonauts | L 34-21 (7-5) |
| October 4 | vs British Columbia Lions | W 49–42 (8-5) |
| October 9 | at Montreal Alouettes | L 45–15 (8-6) |
| October 15 | vs Calgary Stampeders | W 33–13 (9-6) |
| October 21 | at Toronto Argonauts | W 48–28 (10-6) |
| October 28 | vs Saskatchewan Roughriders | L 54–52 (10-7) |
| November 3 | at Winnipeg Blue Bombers | L 30–18 (10-8) |
| November 12 | vs British Columbia Lions | L 34-32 Division Semifinal |