1960 Edmonton Eskimos
In the second season under Keys and first with new general manager Joe Ryan, the club would once again finish with a record of 10-6 and second in the WIFU. After defeating the Calgary Stampeders and the Winnipeg Blue Bombers in the West playoffs, they would head to their fifth Grey Cup since 1949, falling to the Ottawa Rough Riders 16-6 at Empire Stadium in Vancouver.
Jackie Parker wins his third Schenley award, recognizing the Most Outstanding Player in the CFL. Parker had 668 rushing yards and 1,613 passing yards along with 14 combined touchdowns.
| 1960 (12th season) |
| Record: 10-6 (2nd WIFU) |
| Home: 5-3 | Away: 5-3 |
| Playoffs: 4-2 | Lost Grey Cup |
| Head coach: Eagle Keys (2nd season) |
| All-Stars: Johnny Bright, Ed Gray, Roger Nelson, Jackie Parker, Bill Smith. |
| Major award winners: Jackie Parker (Most Outstanding Player) |
| Date | Opponent | Result (record) |
| August 15 | vs. BC Lions | W 33–14 (1-0) |
| August 22 | vs. Saskatchewan Roughriders | W 19–1 (2-0) |
| August 25 | at Winnipeg Blue Bombers | L 14–18 (2-1) |
| August 29 | at BC Lions | W 26–0 (3-1) |
| September 3 | vs. Winnipeg Blue Bombers | L 14–15 (3-2) |
| September 5 | at Calgary Stampeders | W 29–28 (4-2) |
| September 10 | vs. Calgary Stampeders | W 41–10 (5-2) |
| September 16 | at Saskatchewan Roughriders | W 29–6 (6-2) |
| September 19 | vs. BC Lions | W 18–10 (7-2) |
| September 26 | at Winnipeg Blue Bombers | W 15–2 (8-2) |
| September 30 | vs. Saskatchewan Roughriders | W 9–2 (9-2) |
| October 6 | at BC Lions | L 13–21 (9-3) |
| October 8 | vs. Calgary Stampeders | L 11–31 (9-4) |
| October 15 | at Calgary Stampeders | L 17–35 (9-5) |
| October 17 | vs. Winnipeg Blue Bombers | L 17–21 (9-6) |
| October 22 | at Saskatchewan Roughriders | W 13–11 (10-6) |
| November 2 | vs. Calgary Stampeders | W 30–7 Division Semifinal |
| November 5 | at Calgary Stampeders | W 40–21 Division Semifinal |
| November 12 | vs. Winnipeg Blue Bombers | L 16–22 West Final |
| November 14 | at Winnipeg Blue Bombers | W 10–5 West Final |
| November 19 | at Winnipeg Blue Bombers | W 4–2 West Final |
| November 26 | vs. Ottawa Rough Riders | L 6–16 Grey Cup |